The Disease
Hyperuricosuria is characterized by elevated levels of uric acid in the urine. This disease predisposes dogs to form stones in their bladders or sometimes kidneys. The trait can occur in any breed but is most commonly found in the Dalmatian, Bulldog and Black Russian Terrier where Dalmatians are considered to be homozygous for hyperuricosuria.

Hyperuricosuria is inherited as a simple autosomal recessive trait.

Sire

Dam Offspring
Clear x Clear > 100% Clear
Clear x Carrier > 50% Clear + 50% carriers
Clear x Affected > 100% carriers
Carrier x Clear > 50% Clear + 50% carriers
Carrier x Carrier > 25% clear + 25% affected + 50% carriers
Carrier x Affected > 50% carriers + 50% affected
Affected x Clear > 100% carriers
Affected x Carrier > 50% carriers + 50% affected
Affected x Affected > 100% affected
CLEAR

Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene. The dog will never develop Hyperuricosuria and therefore it can be bred to any other dog.

 

CARRIER

Genotype: N / HU [ Heterozygous ]
The dog carries one copy of the mutant gene and one copy of the normal gene. The dog will never develop Hyperuricosuria but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%. Carriers should only be bred to clear dogs. Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above).

 

AFFECTED

Genotype: HU / HU [ Homozygous mutant ]
The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring. The dog will develop ricosuria and will pass the mutant gene to its entire offspring

Source: Laboklin UK www.laboklin.co.uk

 

A lot of people are keen to breed their dog, some owners of male dogs think they will make lots of money from stud work.

Even outstanding champion bulldogs get very little stud work and fail to earn their keep. If a pet dog is used at stud he will start to mark his territory, therefore making a nuisance of himself and if he is a poor example of the breed he may well throw inferior stock, which is the last thing we need.

If a bitch is bred from she should be a very healthy active sort with no health problems. Often the vet and breeders will say pre book her for a c-section which could risk her life in the hands of a non bulldog vet ( many have died that way).

The correct way to do it is let the bulldog go into labour and if the labour is not progressing as it should then a vets advice should be sought. It is fashionable to book a c-section which is doing the breed no favours and therefore we hear the bulldog cannot give birth, when in fact no one has tried.

At least one parent should of being DNA tested clear of HUU, if neither is tested you may very well be mating two carriers together which will lead 25% of the resulting puppies being affected with HUU and could develop bladder stones and at the very least have to spend their life on special food and possibly medication as well.

A lot of puppies are lost by people that don`t have the knowledge to keep them alive or the twenty four hours a day to sit and look after them until they are old enough.

Only the very best examples of the bulldog should be bred from , they should be very healthy and active and able to lead a normal life. They should not be over exaggerated and have no health problems.

 

Perhaps due to the high price of a puppy, a lot of undesirables are breeding bulldogs they do not have knowledge of the breed, they are not breeding to improve just to produce puppies to sell.

These are often the puppies you see in free papers and on line puppy sales ie epupz etc.

The best way is to contact a local bulldog breed club secretary and ask them to recommend someone to you. They know the breed ,they know the breeders and their dogs and if there are known problems with their dogs they will not recommend to you.

The www.bulldogbreedcoucil.co.uk has a list of bulldog clubs throughout the UK.